As researchers try to further describe exactly what is going on in rosacea, more tiny bits of information arise. Here, this abstract is telling us that; Ferritin positive cells are much more prevalent in rosacea sufferers Severe rosacea sufferers have significantly more ferritin positive cells Blood peroxide levels are higher in rosacea sufferers …

2. CD5024 Cream in Phase 3 Trials (Metrocream 1% ?)

Galderma has another rosacea-targeted treatment, until now undisclosed, in the final stages of approval. Hey – how come no one told me?

Could it be possible that the rosacea heavyweight Galderma has kept a new product so secret?
What is this CD5024?
Just what exactly is this CD5024 1% Cream? Galderma …

3. “Glaucoma Gel” Good for Redness: Daily Mail

The Daily Mail continues its interest in rosacea treatments with an article about an unnamed glaucoma treatment that has been formulated as a gel treatment for the redness of rosacea. Of course we know this treatment as Sansrosa. Other names we have seen over the years include COL-118 and CD07805/47. The active ingredient in the glaucoma treatment of mentioned …

4. Ocular Rosacea Video Worth a Watch

Thanks to a tip from Dori, on the Rosacea Support Group Email Group, here is a link to a video of a lecture giving a good overview of ocular rosacea and treatments.
Ocular Rosacea: Curse of the Celts and Celeb…

5. Finacea matches the pH of Skin so Penetrates Well

We know that the pH of skin is around 5.4. The makers of Finacea, Intendis have formulated Finacea to be pH of 4.8, which means that Finacea is reasonably close to the same pH as skin. One of …

6. IPL London Spa Burn Victim Awarded Tens of Thousands in Damages

In 2008 we heard about Charlotte Cripps, a writer for the The Independent was badly burned by an IPL treatment at a London Spa. Today we …

7. Treating Intestinal Bacteria with Xifaxan May Improve Rosacea

Some more recent publicity from Internal Medicine News on the possible link between Small Intestinal Bacteria Overgrowth (SIBO) and Rosacea. In 2008 Rosacea News highlighted a paper that suggested that treating patients with rosacea and SIBO with Rifaximin would improve both their SIBO and rosacea symptoms. That posting has attracted a lot of interest, heading towards 100 comments. Two threads …

8. Finacea Foam Trials Results Look Good

Some recent trial results confirm that Intendis are moving forward with the development of Finacea Foam. The summary of a recent trial, quoted in Skin and Allergy News shows that Finacea Foam is more effective at reducing rosacea symptoms compared to the inactive vehicle. This trial doesn’t show whether Finacea Foam is more effective than Finacea Gel, but does suggest that Finacea Foam likely to …

1. Demodex Infestation: the Missing Link ?

Firmly in the pure speculation category is a recent paper that proposes that pityriasis folliculorum (or demodex mite infestation) is the missing link in our understanding of rosacea. Plainly put, Dr. Forton, a dermatologist from Belgium, suggests that rosacea is a …

2. NRS highlights Neurologic form of Rosacea

The NRS Blog today mentions the recent publications that raise a possible new Subset of Rosacea. Even though this is just a passing reference, it is good to see that the NRS …

3. Elorac Patenting Oral Niacinamide + Oral Azelaic Acid (Finacea)

An unusual patent has surfaced that is suggesting the oral use of azelaic acid. Azelaic Acid is better known as the active ingredient in the topical finacea. This patent suggests an oral treatment that combines niacinamide with azelaic acid. The owner of the patent, Elorac is known from their recent trials of Carbamide Peroxide as a rosacea treatment. Finacea has received some …

4. Sansrosa not Susceptible to Tolerance or Rebound

Some news today from the Phase 2B Sansrosa Trials;

Galderma is now confirming that during the 8 week trial, participants did not suffer from tachyphylaxis or rebound.

This means that if you stop and start sanrosa or continue to use it for an extended period you likely won’t suffer from a rebound effect or from a reduced effectiveness.

This is some good news as it indicates the formulation …

5. Merck Trialling Laropiprant for the Redness of Rosacea

A product from Merck designated as MK-0524, also known as Laropiprant, is to be trialled as a treatment for the redness of rosacea. This is great news for rosacea …

6. Get ready for MetroFoam

A recently updated patent application by Galderma shows that they want to reserve the right to create a Metronidazole Foam product.

Galderma has a long history with topical metronidazole products, starting with Metrogel 0.75%, then adding Metrolotion and Metrocream, and when the patent on the 0.7% Metrogel expired, Galderma created Metrogel 1%.

Past research seems to suggest that it matters little whether you use Metrogel, Metrolotion, …

7. Niacin Flushes More when we are Worried About What Others Think

Continuing his research in facial flushing and anxiety, Dr. Peter Drummond from Murdoch University has published  some new research on social anxiety and facial flushing.

The trial found that Niacin, which is known to induce a facial flush, actually causes more flushing in people that worry about what others think of them.

By blinding participants to whether they were given Niacin or placebo, and measuring facial blood …

8. Powell: Randomized Clinical Trials are not the whole story

Writing in the British Journal of Dermatology, the well known Rosacea Researcher Professor Frank Powell says that research based on randomized clinical trials are not the be-all and end-all for rosacea research. He tells us that there is still room for other sorts of innovation, especially when seeking treatments from your dermatologist. Recently a Cochrane review of 58 clinical trials told us that …

9. Obagi Rosaclear may be better than Metrogel 0.75% + Standard Skincare

Another published abstract that appears to be building the case for the Rosaclear Integrated Rosacea Treatment from Obagi. Although the article …

10. News Shorts: Internet Anxiety, Food Hospital

Some quick links to items from around the web. 1. Internet Searching leads to greater anxiety for melanoma sufferers Of course everyone is now using the internet to read up on everything health related. You may be headed for some unnecessary anxiety though, so be careful. Internet Use and Anxiety in People with Melanoma and Nonmelanoma Skin Cancer …

The FDA announced today that the U.S. Food and Drug Administration approved 35 new medicines in fiscal year 2011. They included “important advances for patients, including: two new treatments for hepatitis C; a drug for late-stage prostate cancer; …

2. Topical Ivermectin + Metrogel from Galderma

An update to the 2009 filing of the patent covering preparations of Ivermectin and Metronidazole has emerged at the USPTO Patent Application Site. That application was in turn a followup to the original French language application 0505918 from 2005. The patent covers many different combinations of ivermectin and metronidazole such as emulsion, cream, gel with ivermectin present in an amount of from 0.01% to …

3. Amneal Pharmaceuticals joins the Generic Oracea War

News today of yet another company in the courts fighting against Galderma for the right to make Generic Oracea. Amneal Pharmaceuticals, based in Gujarat, India, a producer of generic …

4. Pineapple + Cottage Cheese, Get Bromelain from your fridge

Are you searching for a natural therapy to quickly relieve your symptoms? Would you be willing to try freshly crushed pineapple and cottage cheese on your face? Ellen …

5. Scenesse One Step Closer for Erythropoietic Protoporphyria (EPP)

News from Clinuvel that Scenesse (their implant of afamelanotide 16mg) has shown a provable positive effect on EPP sufferers in a US Phase 2 Trial. EPP is an acute intolerance to exposure to sunlight and UV. Sufferers of …

6. Accutane Gaining More Popularity

A new paper that highlights the progress made in recent years by researchers who are seeking to prove that accutane is a viable rosacea treatment.

This growing body of proof is actually quite important because oral isotretinoin is not officially approved as a treatment for rosacea. Doctors can prescribe accutane off-label for use in rosacea, so more comprehensive trials of accutane can only be a good thing. Further, the growing difficulty in finding a doctor who will actually prescribe accutane means that rosacea sufferers need all the proof that they can get their hands on.

A vaccine for acne ? Well it appears that one may actually become a reality. A recent article in the New Scientists explains how targeting a protein called CAMP can …

2. Galderma wanting to show Oracea Maintains Rosacea Remission

A recently posted proposed Clinical Trial has me thinking that Galderma wants to be able to market Oracea as a product to Maintain Rosacea Remission. First Some History …

3. Placebos Get Better Over Time: The Weird World of Placebos

More from the weird and wonderful world of clinical trials and the mysterious Placebo Effect. We know that somehow even dummy pills can kick-start the body’s recovery engine. This latest article from WIRED tells us that drug …

4. Diet and Acne: What the Latest Research Says

September 16th, 2011, by David Pascoe | acne treatments, diet | Edit

Over at the Acne Blog, Daniel Kern has posted a few high level posts relating to recent readings he has undertaken on the topic of diet and acne. Daniel …

5. Oracea set to generate $260m in 2011

An interesting note from the detailed interim judgement in the ongoing patent dispute between Galderma and Mylan. As part of the proceedings Mylan looked at the on-going Oracea sales and projected that Galderma can expect to receive around $260 million in 2011. MYLAN PHARMACEUTICALS INC., v.  GALDERMA LABORATORIES, L.P.; et. al. …

Startling news today from the Clinuvel Blog: Melanin also has the ability to protect from radioactive emissions like X-rays and Gamma-rays. How interesting that the chemical that …

2. Mylan Violates The Chang Patent for Oracea

Another step in the ongoing battle between Galderma and Mylan over the right to manufacture generic Oracea. A judge has declared that Mylan infringes 1 of the patents that protects Oracea from generic copies. Some History …

3. How Much Sunscreen Should I Use?

Another fabulous data visualisation from Information is Beautiful. This time David McCandless tackles the thorny issue of How Much Suncreen Should I Wear ? The Sunscreen Smokescreen July 11, 2011 It started with a question. It always does. This time, the question was simple: How much sunscreen should I wear? I’m …

4. NRS Funds New Rosacea Studies for 2011

In the Summer 2011 Rosacea Review, The National Rosacea Society announced that they are funding 3 studies in new areas of rosacea research. This is great news; not only is the NRS continuing to fund 5 existing studies, it is funding …

5. NRS Continues Leading Edge Research Funding

The National Rosacea Society recently announced that they will be continuing to fund 5 existing rosacea research streams. Confirming their faith in the on-going NRS sponsored research, the NRS has announced additional funding to the following researchers. 1. Dr. …

6. Lupin and Medicis Agree Over Generic Solodyn

In contrast to the ongoing disputes over generic Oracea, the makers of the low-dose minocycline Solodyn, Medicis have entered into a joint development and sales agreement with Lupin Pharmaceuticals.

Solodyn is a form of Minocycline, a member of the tetracycline famaily, available in 8 strengths, prescribed based primarily on your weight.

7. Low Dose Accutane from St Thomas’ Hospital in London: Daily Mail

The Daily Mail has another of its semi-regular stories on Rosacea today. This time the article highlights the use of low dose accutane to treat hyper keratinisation, slow down sebum production, and also serve as an anti-inflammatory and anti-bacterial agent.

Below is a wonderfully rich graphic that tries to help visualise the available evidence for the efficacy of dozens of oral supplements. The aim of the creators is to visualise tangible health benefits when taken orally by an adult with a healthy diet. Only human, randomised placebo-controlled trials were used to create this graphic. Information is Beautiful: Snake Oil? …

2. Gallo to trial Aminocaproic Acid as Cathelicidin Inhibitor

Just posted are some details of a new trial rising out of the work of Dr. Richard Gallo’s group at the University of California, San Diego. Gallo is well known for his work on the relationship between antimicrobial peptides such as cathelicidin, and rosacea. The trial will compare topical 25% aminocaproic acid (ACA) mixed with Vanicream vs Vanicream on its own. The …

3. Allergan buying Vicept Therapeutics to get V-101 / Oxymetazoline

News today that Allergan are buying the privately held pharmaceutical company Vicept Therapuetics. The aim of many small startup companies is to be acquired by a larger company, Vicept telling us that “We believe Allergan …

4. Rosacea Cure eBooks: All Just SPAM?

There is a seedy dark side to the internet. OK you knew that already, but perhaps there are forces at play on the internet that are more subtle than you realise. Lets turn our focus toward the emergence of the “Rosacea Cure eBook” Phenomenon. Over the last few years there are more and more web sites that exist to solely sell you …

5. Metrogel, Finacea and Oracea are Best for Rosacea

A systematic review of the available rosacea research confirms that Metrogel, Finacea and Oracea are effective for moderate to severe rosacea. One study further found cyclosporine 0.05% ophthalmic emulsion effective for ocular rosacea. This review looked at the published results of 58 trials to note bias and construct a high level summary of the results. No Surprises Here It will come as …

6. Cosmetics and Makeup work fine applied after Metrogel

This research comes up with the finding that using a foundation after applying Metrogel 1% won’t worsen rosacea symptoms. Most of the participants in the trial were happy with the appearance of foundation, when used in combination with Metrogel.

The authors tell us that there is little research into whether makeup both makes rosacea worse or whether those who suffer from rosacea can also successfully use makeup like foundation.

The Pharmaceutical Research and Manufacturers of America tells us that there are currently 9 drugs in development for rosacea. I was initially curious as to how counted nine. Read on if you want to see how they get to this number. 277 Medicines in Development For Skin Diseases Washington, D.C. (June 13, 2011) — America’s biopharmaceutical …

2. Why Do New Drugs take SO LONG to be Developed?

For everyone waiting on the latest and greatest new treatment for rosacea, new drugs seem to take forever to make it to the market. Taking a step back and looking at new drug development in general, it is very sobering to read how few drugs actually make it to an approved product; THE DRUG DISCOVERY , DEVELOPMENT AND …

3. Final FDA Approval of Sansrosa, expect 15 months post Phase III

A popular topic online at the various rosacea forums is to guess when Sansrosa will become available. So far all guesses have proved way way too optimistic. Given that we believe that the process is in the later stages of Phase III, what sort of best outcome possible, educated guess might be worth offering up? Once the Phase III process completes (which itself …

4. Riversol: From idea to a Rosacea Product

I thought this article from the Vancouver Sun was quite interesting from the point of view of developing new products for rosacea sufferers. Just how do you get from something that you think might work, to a product …

5. Galderma blocking Impax making Generic Oracea

The last we heard from Impax Laboratories was in late 2009 when they had filed an Abbreviated New Drug  Application (ANDA 91-447) to produce a generic version of Oracea. …

6. Inactive Ingredients Just as Important as Active Ingredients

Rosacea sufferers get good at looking through ingredient listings. What magical ingredient has been included in this product that might help me? But you should keep reading and take notice of everything listed.

7. How do you cope with Rosacea at Work?

The NRS recently highlighted the possible negative effects of rosacea in the workplace and on their career.

As well any physical symptoms such as facial burning, blurred vision and debilitating flushing, the secondary worries about what others will think about your appearance make it tough for rosacea sufferers at work.

The owner of the site acne.org, Daniel Kern has created an acne treatment regime that is cheap and simple. It looks to me like any benefits to rosacea sufferers are yet to be discovered. acne.org is a large online community of acne suffers that includes a small area for rosacea sufferers. The site is run mostly by volunteers and doesn’t accept any …

2. Most Patients use Steroids for Trivial Problems

Steroid Induced Rosacea is, sadly, one hot topic.

I know this because the blog posting Treating Steroid Induced Rosacea is one of the most visited pages on this site, and is currently approaching 1000 comments. Unfortunately many …

3. Sansrosa Parallel Phase III Safety and Efficacy Trial Announced

News today of a parallel Sansrosa Phase III Trial. This just announced trial is shorter than the Long Term (52 week) Safety Trial, and seeks to confirm that Sansrosa Gel (CD07805/47) is more effective than the inactive vehicle gel and is itself a safe treatment. Trial ID: NCT01355458 (seems to be somewhat duplicated with NCT01355471) …

4. Vanicream Moisturizing Skin Cream User Reviews

I harp on about this a lot, but I think it is worth repeating. A gentle skin care regime is a good thing for your rosacea. We know …

5. Tetrapeptide-14: Now available for Eye Puffiness and Redness

Some news today promoting a product claimed to reduce the appearance of under eye puffiness. Tarte Dark Circle Defense claims the inclusion of a Helix Biomedix designed peptide sequence known as Tetrapeptide-14 is responsible for the anti-inflammatory actions of the concealer.

6. AzaClear: Moisturizer with Azelaic Acid and Niacinamide

Epikinetics Pharma has pushed out a press release today (reproduced in full on sfgate.com …

7. Why should I Cleanse and Moisturize my dry, oily, flaky SD skin?

I came across this thread in the archives and thought it was worth highlighting it and pushing it out again.

The question asked is a good one – how can cleansing and moisturizing the dry flaky and oily SD skin be a good thing? If you have ever wondered why this is so, read on.

It was interesting to read again how for severely sensitive skin, repairing …

8. FTC Gets Tough on Acai Berry Supplement Sites

Recently the Federal Trade Commission announced that it was taking legal action against businesses that operate deceptive supplement web sites, specifically sites that selling Acai Berry based products.
What does this have to do with Rosacea?
A fair question. As the internet has become a more and more popular source for health related information, the trustworthiness of web sites has become more and more important.

9. Atopiclair, Eletone, MimyX: Barrier Creams with No Active Ingredients

Thanks to Beth, here is some more information about a class of FDA Approved “Medical Device” creams. This class of creams are prescription only, contain no active molecules and are approved for sale to treat medical conditions under via the provisions of …

1. LA Clinic looking for Oracea Biomarkers Study Participants

The Vitligo and Pigmentation Institute of Southern California is hosting part of the trial to evaluate Rosacea-related Inflammatory Biochemical Markers in Adult Skin When Treated With Oracea  vs Placebo. This trial is looking to prove changes in inflammatory markers like the peptide LL-37 and the MMP family match the improvement seen when taking Oracea. The trial is scheduled to involve 170 participants at …

2. Why, Oh Why Did I Get Rosacea ?

I hear you.

My skin was great. I have had beautiful skin all my life, but now wham! rosacea has reared its ugly head.

Well the NRS Blog has an answer to this plea. It is all about your risk profile. If you are over 30 with fair skin, have a relative with rosacea and are of Northern European Ancestry then the statistics suggest that you are …

3. Galderma Big Profits Great for Texas

An interesting article from the Business section of the Star-Telegram about the local presence of Galderma in Fort Worth, Texas. Galderma is one of the key companies for rosacea sufferers to follow given their products such as Cetaphil, Metrogel, Oracea and the in-development Sansrosa. Swiss skin-care company thrives even during hard times, executive notes at …

4. Vicept Oxymetazoline V-101 Cream More Phase II Data, on to Phase III

A Press Release today (Vicept are happy to generate publicity at every step of their development) touting more Phase II Study results for their Oxymetazoline based V-101 product. V-101 is a topical slated to treat the redness of …

5. The BEST Treatment for Rosacea

Once you have been diagnosed with rosacea, everyone naturally wants to know What is the best treatment for rosacea? Wouldn’t it be great if there was a simple answer to this question that satisfied everyone who has rosacea! Hopefully it doesn’t come as a surprise to find out that there is no known panacea for rosacea. This high level paper …

6. Generic Oracea Legal Trial now in July 2011

I have been watching for a while to see for any developments in the legal proceedings between Mylan and Galderma. These proceedings will determine whether Mylan is allowed to sell Generic Oracea. This is of interest to many rosacea sufferers who consider that Oracea is too …

7. Medicis and Anacor to Develop Boron Treatments for Acne

Even though this press release relates to Acne, it is still interesting to see companies searching for the next killer acne treatment. Whilst only some acne treatments are successful as rosacea treatments, we can still …

8. Green Jelly Beans Linked to Acne!

OK so now I have gotten your attention. Have read of this comic. Lets talk after you finish reading it. xkcd: Significant …

9. Nailfold Capillaroscopy: If only Rosacea was that Easy to Diagnose

I thought this abstract was interesting because of its failure. The authors proposed that a passive diagnostic test known as Nailfold Cappillaroscopy could be used to test for rosacea.

This short abstract from Dr. Richard Gallo is an introduction to an article further on in the journal edition from Dr. Ahrens et al. Gallo’s interest is piqued by the possibility of a coordinated defense effort from the permeability and antimicrobial barriers of the skin. Ahrens was able to show that certain Antimicrobial peptides (AMPs), called beta-defensins were upregulated (i.e. they …

2. Dry Eye is a common precursor to Ocular Rosacea

This abstract suggests that dry eye may be an early sign of ocular rosacea. Tear function tests could help the early diagnosis of ocular rosacea, according to the authors. Currently there is no definitive diagnostic test for ocular rosacea, it is based on clinical symptoms. One proposed diagnostic test is high abundance of oligosaccharides in the tear fluid of patients with rosacea. …

3. Ever heard of a Rx Cream with NO ACTIVE INGREDIENTS?

In all of your internet searching for treatments, have you ever come across a FDA approved, prescription-only treatment that claims to have no active ingredients ? Would you stop and think What is that all about? Well I did. The supporting web site for Promiseb Topical Cream  (online at http://promiseb.com/) contains a very …

4. Itchy Gritty Eyes may be Blepharitis

An unusually useful article about Blepharitis today from The Herald Times Reporter, Manitowoc, Wisconsin. (htrnews.com). Itchy, sandy feeling in eyelids may be blepharitis Question: What causes my eyelids to be itchy and sandy in the mornings? Answer: The most likely cause of your symptoms is something called blepharitis, or inflammation of the eyelids, and …

5. Sansrosa starts Phase 3 Trials (again)

News today that Galderma has listed CD07805/47 as entering large scale Phase III trials. Under the previous owners of the Brimonidine-based technology Collagenex, the product then known as Sansrosa …

6. The Rosacea App: A Rosacea Web Site in your pocket

This is a first. A major pharmaceutical company has released a smart phone app for rosacea sufferers. Intendis, the makers of Finacea, have created a program that you can carry around for easy reference.

Built with the help …

7. Finacea plus Low Dose Accutane to treat Seborrheic Dermatitis + Rosacea + AK

Below is a recent paper suggesting that combining Finacea with Low Dose Accutane is a useful treatment for rosacea concomitant with seborrheic dermatitis. The patient was also suffering from Actinic Keratosis (pre-cancerous skin lesions). The patient experienced relief from both rosacea and seborrheic dermatitis, two conditions that together sometimes prove tricky to treat. Bear in mind, though, that this paper …

8. Intendis makes a mobile phone app for Rosacea

Intendis, the makers of Finacea, have announced that they are to produce an application for mobile phones to help sufferers of rosacea manage their symptoms. To be launched in March, the Rosacea Info App will be available for iPhone, BlackBerry and Android. Previously Rosacea News covered a program called AcneApp that purported to treat acne by displaying a solid red or …

9. Galderma, with Oracea looking for Inflammatory Pathway Markers

Seemingly wanting to help answer the question How do tetracyclines help Rosacea? Galderma has announced a large trial to measure the changes in inflammatory pathway markers when you take Oracea.

Whilst the trial only directly mentions LL-37 and MMP I would expect other well known markers to be measured as well.

If the researchers include markers that can be proven to be indicative of rosacea disease, …

10, The Placebo Effect is a very strange thing indeed

How exactly does the mind play a role in the way that medicines help us ? How come even when we know the treatment is fake, we can get better ? Should we be asking our doctor for a bottle of placebo pills the next time we visit ? I would love to know the answer to these questions and …

11. Xylometazoline (Otrivin) is another red face treatment

A brief extract today covering a paper detailing how the topical Xylometazoline can be used to treat the redness of rosacea.

Similar to oxymetazoline, xylometazoline is marketed as a nasal decongestant under many brand names. Brands you may come across include Otrivine, Otrivin, Sinutab Nasal Spray, Cirovin and Novorin.